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How to run a systematic review in 2025

A practical checklist for registering, searching, screening and synthesizing evidence from start to finish.

A systematic review is only as strong as its methods. Start with a protocol and register it before you search. Build a search string with a librarian, run it across multiple databases, and screen every record in duplicate. Extract data with a pre-piloted form, assess risk of bias with the right tool for your design, and synthesize only when heterogeneity is understood. SciExpert bundles protocol drafting, dual screening, extraction reconciliation, meta-analysis and PRISMA reporting in one workspace.

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