How to use Meta-Analysis Engine

Fixed and random effects models with DerSimonian-Laird and Paule-Mandel estimators, heterogeneity statistics, Egger's test and trial sequential analysis.

Before you start

• • Effect sizes with standard errors, or 2x2 counts per study

Steps

1. 1

   Open Meta-Analysis Engine

   Sidebar → Meta-Analysis Engine.

2. 2

   Enter or paste your study data

   One row per study. Extract Data and Literature Synthesis Tables can produce this table for you.

3. 3

   Choose the model

   Random effects when studies differ in population or design; fixed effect only when they are near-identical.

4. 4

   Read heterogeneity honestly

   Check I², tau² and the prediction interval before interpreting the pooled estimate.

5. 5

   Check small-study effects

   Inspect the funnel plot and Egger's test, and use trial sequential analysis to see whether the evidence is conclusive.

6. 6

   Export the outputs

   Download the forest and funnel plots plus the underlying numbers as PDF and CSV.

Tips

• • Save the model configuration as a preset so every review in the project uses the same settings.

Troubleshooting